FIELD: chemistry.
SUBSTANCE: invention relates to compounds of formula (I):
,
wherein in general formula (I) n1 is selected from 0 or 1; Z is 
, where the carbon atom marked with * represents a center of asymmetry; each of R1, R3, R4, R5, R6, R7, R8 and R9 is independently selected from H or D; R2 is selected from H, D or F; each of L1 and L2 is independently selected from CD2, CHD or CH2; X is selected from NH, ND or O; R10 is H, D or 
, where each of R2', R3', R4' and R5' is independently selected from H, D, halogen, cyano, hydroxy, 
, 
, 
, 
, substituted or unsubstituted (C1-C12)alkyl, substituted or unsubstituted (C1-C12)alkoxy, (C2-C20)heterocycloalkyl or deuterated (C2-C20)heterocycloalkyl; where each of Ra and Rb independently is H, (C1-C12)alkyl, (C1-C12)alkylacyl; each of Rc and Rd independently represents H or (C1-C12)alkyl; Re is 
or (C2-C20)heterocycloalkyl; wherein each of Re1 and Re2 independently represents H or (C1-C12)alkyl.
EFFECT: compounds are able to regulate activity of immunological cytokines, thus effectively curing cancer and inflammatory disease.
14 cl, 3 tbl, 78 ex
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