UREA DERIVATIVES AND THERAPEUTIC USE THEREOF IN TREATING, AMONG OTHER THINGS, RESPIRATORY TRACT DISEASES Russian patent published in 2016 - IPC C07D471/04 C07D401/12 A61K31/437 A61K31/4427 A61P29/00 A61P11/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I) or its pharmaceutically acceptable salt thereof, wherein R¹ represents radical of formula (IA), (IB), or (IC), wherein R^4b is C₁-C₆ alkyl, C₃-C₆ cyclo alkyl, phenyl, which is optionally substituted 1-2 substitutes selected from halogen, hydroxy or O-benzyl; or radical of formula (IIa) or (IIb), wherein n equals 1 or 2; and R³ and R⁴ are independently h or C₁-C₆ alkyl; R^3b is optionally substituted C₁-C-₆ alkyl, wherein substitute is selected from (C₁-C₆) alkoxy; y represents-O-; A is a cyclo-alkylene radical, having 5, 6 or 7 atoms of ring condensed with phenyl ring; R² represents radical of formula (IIIa), (IIIb), (IIIc), wherein q is equal to 0, 1, 2 or 3; R⁷ is -CH₃; R⁸ is -CH₃ or C₂H₅ and each presence R⁶ is independently H, C₁-C₆ alkyl. Invention also relates to pharmaceutical composition inhibiting activity of MAP-kinase p38 containing effective amount of compound of formula I, together with one or more pharmaceutically acceptable carriers.

EFFECT: technical result is compound for use in treating disease or condition, which has positive result of MAP-kinase p38 inhibiting.

11 cl, 2 tbl, 22 ex

(I)

(IA) (IB) (IC)

(IIa) (IIb)

(IIIa) (IIIb) (IIIc)