DERIVATIVES OF TRIAZOLEBENZAZEPINE, METHODS OF THEIR SYNTHESIS, INTERMEDIATE COMPOUND FOR THEIR SYNTHESIS, PHARMACEUTICAL ANTIHISTAMINIC COMPOSITION AND METHOD OF ITS PREPARING Russian patent published in 1999 - IPC

Abstract RU 2126802 C1

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to new derivatives of triazolebenzazepine of the general formula (I) . Pharmaceutical antihistaminic composition has a compound of the formula (I) as an active component taken at therapeutically effective dose. Compounds of the formula (I) show antiallergic activity. Invention claims compounds of the formula (VII) , its additive salts or stereochemically isomeric forms where each of dotted line means independently each of other optionally a bond, and compounds of the formula (XIII) . Invention proposes eight methods of synthesis of compounds of the formula (I). Methods ensure to synthesize new valuable derivatives of triazole-benzazepine showing antiallergic activity and their using for preparing pharmaceutical compositions on their base for treatment of patients with allergic sicknesses. EFFECT: improved method of synthesis of new triazolebenzazepines, enhanced effectiveness of compounds. 17 cl, 26 ex

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RU 2 126 802 C1

Authors

Frans Ehduard Zhansen

Zhan Fernan Arman Lakranpe

Izabell' Noehll' Konstans Pilat

Dates

1999-02-27Published

1993-11-25Filed