DERIVATIVES OF BENZOCYCLOHEPTENE OR BENZOXEPINE, A METHOD OF THEIR SYNTHESIS, INTERMEDIATE COMPOUNDS AND A PHARMACEUTICAL COMPOSITION Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to new compounds of the general formula (I) R₁-R₄ where X - oxygen or group CHR; C₁-C₇ (identical or distinct) - hydrogen or R₁-alkyl being R₅ together with R can forms a bond; R₅ - hydrogen or hydroxy-group, or R₇ together with R₆ forms a bond or a group -O-; is a group R₁₀ where R₁₁ and together with carbon atom with which they are bound form nitrogen-containing heterocycle, and their N-oxides and pharmaceutically acceptable salts. These compounds are power activators of potassium channels. On the base of synthesized compounds a pharmaceutical composition is prepared that shows relaxing effect on smooth muscles. Invention describes also a method of synthesis of compounds of the formula (I) that involves interaction of the corresponding ketone with organometallic compound followed by removing protective groups to obtain the corresponding intermediate compounds and this process is carried out in the presence of acid or acid chloroanhydride. EFFECT: improved method of synthesis. 13 cl, 2 tbl, 9 ex