FIELD: medicine, pharmacy.
SUBSTANCE: invention describes a sustained-release composition comprising the following components: (1) a derivative of LH-RH of the formula: 5-oxo-Pro-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NH-C2H5 or its acetate, or its salt taken in the amount from 14% (mas./mas.) to about 24% (mas./mas.) of the total composition mass; (2) 3-hydroxy-2-naphthoic acid or its salt, and (3) polymer of lactic acid or its salt with average-mass molecular mass from 15000 to 50000 Da wherein the content of polymers with molecular mass from 5000 Da or below is 5% by mass or below and wherein the molar ratio of 3-hydroxy-2-naphthoic acid or its salt to derivative of LH-RH or its salt = from 3:4 to 4:3. Also, invention describes a method for preparing the composition and a medicinal preparation comprising the regulated composition. Proposed composition provides the constant release rate for the prolonged time based on inhibition of the parent intensive release of a pharmaceutically active compound.
EFFECT: improved and valuable properties of composition.
17 cl, 8 tbl, 22 ex
