FIELD: chemistry of peptides, medicine, drugs, pharmacy.
SUBSTANCE: invention relates to pharmaceutical compositions containing polymer of lactic and glycolic acids with the ratio of average molecular mass and medium-numbered molecular mass about 1.90 or less, or its salt and physiologically active peptide as agonist of LH-RH of formula: 5-oxo-Pro-His-Trp-Ser-Tyr-Y-Leu-Arg-Pro-Z (I) wherein Y means D-Leu, D-Ala, D-Trp, D-Ser (tBu), D-2-Nal or D-His; Z means HN-C2H5 or Gly-NH2 or its salt, in particular, peptide of the formula: 5-oxo-Pro-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NH-C2H5 (II) or its acetate, and to polymer of lactic and glycolic acids with the ratio of average molecular mass and medium-numbered molecular mass about 1.90 or less. Also, invention relates to a method for preparing indicated polymer and to a microsphere containing indicated polymer and peptide of the formula (II), and to a medicinal agent used in prophylaxis or treatment of prostate cancer, prostatomegaly, endometriosis, uterus myoma, metrofibroma, premature sexual maturation and dysmenorrhea, or for a contraceptive agent comprising indicated microsphere, and to methods for prophylaxis or treatment of indicated diseases. Invention provides preparing compositions with delayed release and containing physiologically active substance of peptide nature and providing the stable rate of release of active substance for the prolonged period (up to 1 month) in inhibition of high initial release of indicated active substance.
EFFECT: improved preparing method, valuable medicinal properties of composition.
37 cl, 4 tbl, 9 ex
