FIELD: molecular biology, biotechnology. SUBSTANCE: synthetic inducible eucaryotic promoter for regulation of gene transcription is obtained by insertion of one or more members into natural promoter hMT-IIA that contains a natural member and responsible for metal induction and determining induction by glucocorticoid. Synthetic promoter based on natural promoter MMTV-LTR that contains a natural member determining for glucocorticoid response is obtained by insertion of one or more metal-inducing member into natural promoter. Invention ensures to provide synergistic level of gene expression in an eucaryotic expression system. EFFECT: synthetic promoter indicated above. 13 cl, 1 dwg, 4 tbl, 5 ex
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