FIELD: genetic engineering, virology, medicine. SUBSTANCE: invention relates to the improved retroviral vectors. Vectors are constructed on the basis of parent vectors MON and MIN based on MLV. Improved vectors are characterized by the presence of deletion in encoding regions MLV gag, pol and env that ensures to avoid the homologous recombination. Said vectors provide safety and effective expression of foreign genes. Vectors can be used in genetic therapy. EFFECT: improved and valuable properties of vectors. 13 cl, 13 dwg, 3 tbl, 3 ex
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