HYBRID PROTEIN, HYBRID GENE, METHOD OF PREPARING A HYBRID PROTEIN, VACCINE AGAINST UPPER RESPIRATORY WAY VIRAL DISEASE, BACULOVIRAL EXPRESSION VECTOR (VARIANTS) Russian patent published in 1998 - IPC

FIELD: molecular biology, genetic engineering, medicine. SUBSTANCE: hybrid protein has an immunogenic protein or its fragment of parainfluenza virus type-3 bound with immunogenic protein or its fragment of respiratory-syncytial virus of type-A. Invention proposes also hybrid gene encoding hybrid protein, method for preparing hybrid protein and vaccine against upper respiratory way diseases that contains hybrid protein. Invention proposes also baculoviral expression vectors pACDR7, pD2RF-HN, pD2F-G providing expression of hybrid protein. Invention provides preparing the combined immunogens containing protective antigens. EFFECT: simplified development of mixed vaccines, improved method of preparing. 12 cl, 3 tbl, 39 dwg