DERIVATIVES OF 3(2)-PYRIDAZINONE, A PHARMACEUTICAL COMPOSITION, A METHOD OF TREATMENT Russian patent published in 1999 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to new derivatives of 3(2)-pyridazinone of the general formula (I) where R¹ - hydrogen atom, phenyl, methyl substituted with CH₃O or CH₃SO₂NH, C₂-C₄-alkyl substituted with R⁸R⁹N, C₃-C₅-alkenyl substituted with phenyl optionally substituted with halogen atom; one of A and B is hydrogen atom and another - a group of the formula (II) where R² and R³ - hydrogen atom independently, C₁-C₄-alkyl or they form piperazine or homopiperazine ring with adjacent group -N(CH₂)_nN-; R⁴ - hydrogen atom or C₁-C₄-alkyl; R⁵,R⁶ and R⁷ - hydrogen atom, C₁-C₄-alkoxy-group, CH₃SO₂NH; X - a simple valent bond, oxygen atom or a group -CH=CH-; m = 0-1; n = 2-3; R⁸ and R⁹ are C₁-C₄-alkyl independently or with nitrogen atom to which they are bond form morpholino- or 4-R¹⁰-piperazino-group where R¹⁰ is C₁-C₄-alkyl substituted with phenoxy-group or C₃-C₅-alkenyl substituted with phenyl-group or their acid-additive salts showing antiarrhythmic activity. Invention relates to also a pharmaceutical composition containing an effective amount of indicated compound in mixture with pharmaceutically acceptable carriers, diluting agents and/or filling agents. Invention proposes a method of an antiarrhythmic treatment that involves a prescription to patient an effective amount of indicated compound or its pharmaceutically acceptable salt. Activity of proposed compounds exceeds that of the known preparation, for example, sotalol. EFFECT: improved method of synthesis and treatment, enhanced activity of compounds synthesized. 6 cl, 4 tbl, 1 dwg