ASCOMYCINS, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF Russian patent published in 2001 - IPC

FIELD: organic chemistry, antibiotics, pharmacy. SUBSTANCE: invention relates to novel ascomycins of the general formula (I) where Y means phenylene; Z is taken among carboxyl and physiologically hydrolyzable hydroxycarbonyl or alkyl, alkoxyl, alkylamino- or dialkylamino-group carrying from 1 to 4 carboxylic or physiologically hydrolyzable hydroxycarbonyl groups: Q-C or S; R¹ is H, alkyl or aryl; R² is hydrogen atom or hydroxyl; R³ is methyl, ethyl, propyl or allyl; R⁴ is hydroxyl or alkoxyl-group; R⁵ is oxo-group or (H, OH); R⁶ is oxo-group, (H, OH) or (H, alkoxyl-group); n is the whole number 1 or 2 and these compounds are in free from or as in pharmaceutically acceptable form. Compounds show anti-inflammatory activity. Invention describes also method of their synthesis and pharmaceutical composition based on thereof. EFFECT: new ascomycins indicated above, improved method of synthesis, valuable medicinal properties. 15 cl, 2 tbl