FIELD: generic engineering. SUBSTANCE: method of preparing protein eliciting activity of granulocyte-colony- -stimulating factor (GM-CSF) of primates is developed. Method involves culturing yeast or procaryotic cells after their transformation with recombinant vector containing gene that encodes polypeptide of the known amino acid sequence. Producing protein is the indicated human factor (CSF-Thr or CSF-Ile) or gibbon factor (CSF-G). After culturing protein is isolated and purified. EFFECT: increased purity and biological activity of recombinant protein obtained. 7 cl, 7 dwg, 6 ex
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