HYDROXAMIC ACID DERIVATIVES, METHOD OF THEIR SYNTHESIS, DRUG AND METHOD OF ITS PREPARING Russian patent published in 1999 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of hydroxamic acid containing three cyclic substituents of the formula (I) where R¹ - cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl; R² - the saturated 5-8-membered monocyclic or bridge nitrogen-containing heterocyclic ring that being as a monocycle has optionally NR⁴, O, S or SO₂ as a ring and/or possibly substituted at one or more carbon atom with hydroxyl, lower alkyl, lower alkoxy, oxo- or ketalized oxo-group, carbamoyl, monoalkylcarbamoyl or dialkylcarbamoyl; R³ is 5- or 6-membered nitrogen-containing heterocyclic ring bound through nitrogen atom and has optionally nitrogen or oxygen atom as an additional ring member, optionally substituted with oxo-group at one or two carbon atoms that are adjacent to binding their nitrogen atom and can be condensed with benzene ring; R⁴ - H, alkyl, phenyl or protective group; m = 1 or 2; n = 1-4; and their pharmaceutically acceptable salts that are inhibitors of collagenase and can be used for delay of development and prophylaxis of articulation degeneration diseases. EFFECT: improved method of synthesis, prophylaxis of articulation disorders. 24 cl, 5 tbl, 27 ex