DOLOSTATINE ANALOG Russian patent published in 1999 - IPC

Abstract RU 2132334 C1

FIELD: organic chemistry, peptides. SUBSTANCE: invention relates to peptides of the general formula (I) where R1 is C1-7-alkyl; R2 is C1-4-alkyl; X is C1-5-alkyl; R3 is a lower alkyl; B - is C1-5-alkyl; D is C1-5-alkoxy; M - phenylalanine; R4 - H; R5 - H or benzyl; d = 0 or 1, or their salts showing the improved therapeutic properties for treatment of patients with neoplasms as compared with dolostatine-10. Proposed analog can be synthesized by conventional methods unlike to the latter. EFFECT: improved therapeutic properties. 2 cl, 2 tbl, 2 ex

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RU 2 132 334 C1

Authors

Andreas Khaupt

Bernd Janssen

Kurt Ritter

Dagmar Klinge

Gerkhard Kejl'Khauer

Sintija Romerdal'

Tereza Barlozzari

Ksiao-Dong Kvian

Dates

1999-06-27Published

1993-12-04Filed