CYCLOPEPTIDES OF SALTS THEREOF, METHOD OF PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS, METHOD OF PREPARING THEREOF, AND METHOD OF TREATMENT Russian patent published in 1999 - IPC

FIELD: medicine. SUBSTANCE: invention describes compounds of formula I: cyclo(A-B-C-D-Arg) wherein A is D-Val; B is L- or D-Phe; C is L-Asp, D-Asp of D-Asp (O-C₁-C₄-alkyl and D- Gly or Ala, at least two of amino acid residues being in D-form, and also salts thereof. Compounds act as integrine inhibitors and are useful for prophylaxis and treatment of diseases of blood circulation system and therapy of tumors. Present invention also describes method of preparing compounds of formula I, pharmaceutical compositions based on compounds and method of treatment of diseases associated with inhibiting integrine receptor ligand binding, using compounds of formula (I) in daily amount of 0.01-2 mg/body weight. EFFECT: more efficient treatment method. 7 cl, 3 ex, 1 tbl