NEW MARKER FOR THE DIAGNOSTICS OF PANCREATIC CANCER Russian patent published in 2023 - IPC C07K5/10 C12Q1/37 G01N33/574 G01N33/58 

FIELD: biotechnology.

SUBSTANCE: group of inventions relates to a chromogenic peptide for use in diagnosing pancreatic cancer. The following compound of formula 1 is proposed: X1-Thr-Thr-Ala-Arg-X2, where X1 contains or consists of a C1 component, and X2 contains or consists of a C2 component, while C1 and C2 are a pair of a fluorescence donor and a fluorescence acceptor. Proteolytic cleavage of the compound into fragment 1 containing X1 and fragment 2 containing X2 results in a detectable signal. Also the following is proposed: a kit for diagnosing pancreatic cancer containing the specified compound, a method of in vitro detection of protease activity in the biological fluid of a subject, which may contain a proteolytic enzyme derived from pancreatic cancer cells, and a method of treating pancreatic cancer.

EFFECT: inventions are applicable to the rapid and non-invasive detection of pancreatic cancer or to the monitoring of a subject suspected of having pancreatic cancer, with increased risk of developing pancreatic cancer, or previously suffering from pancreatic cancer.

14 cl, 4 dwg, 3 tbl, 3 ex