FIELD: biotechnology.
SUBSTANCE: group of inventions relates to a chromogenic peptide for use in diagnosing pancreatic cancer. The following compound of formula 1 is proposed: X1-Thr-Thr-Ala-Arg-X2, where X1 contains or consists of a C1 component, and X2 contains or consists of a C2 component, while C1 and C2 are a pair of a fluorescence donor and a fluorescence acceptor. Proteolytic cleavage of the compound into fragment 1 containing X1 and fragment 2 containing X2 results in a detectable signal. Also the following is proposed: a kit for diagnosing pancreatic cancer containing the specified compound, a method of in vitro detection of protease activity in the biological fluid of a subject, which may contain a proteolytic enzyme derived from pancreatic cancer cells, and a method of treating pancreatic cancer.
EFFECT: inventions are applicable to the rapid and non-invasive detection of pancreatic cancer or to the monitoring of a subject suspected of having pancreatic cancer, with increased risk of developing pancreatic cancer, or previously suffering from pancreatic cancer.
14 cl, 4 dwg, 3 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PEPTIDE VECTORS | 2004 |
|
RU2361876C2 |
| METASTIN DERIVATIVES AND APPLICATION THEREOF | 2006 |
|
RU2430107C2 |
| METASTIN DERIVATIVES AND USE THEREOF | 2007 |
|
RU2454425C2 |
| CONJUGATES OF CYTOTOXIC AGENTS WITH PEPTIDES | 2007 |
|
RU2457218C2 |
| GLP-1 ANALOGUE DERIVATIVE OR ITS PHARMACEUTICALLY ACCEPTABLE SALTS AND THEREOF APPLICATION | 2010 |
|
RU2565536C2 |
| GLYCATED PEPTIDE GLP-1 | 2009 |
|
RU2543157C2 |
| A CONJUGATE CONTAINING A NEUROTENSIN RECEPTOR LIGAND AND ITS APPLICATION | 2015 |
|
RU2743781C2 |
| NEW OCTAPEPTIDE COMPOUNDS REPRESENTING SOMATOSTATIN DERIVATIVES | 2009 |
|
RU2547940C2 |
| CONTRAST AGENT AIMED AT UROKINASE PLASMINOGEN ACTIVATOR RECEPTOR | 2005 |
|
RU2394837C2 |
| PEPTIDES HAVING AGONISTIC ACTIVITY ON NEUROPEPTIDE-2 RECEPTOR (Y2R) | 2006 |
|
RU2383553C2 |
