FIELD: chemistry.
SUBSTANCE: invention relates to synthesis of insulinotropic peptides, which are synthesised using an approach based on solid-phase and liquid-phase (hybrid) synthesis. Overall, said approach involves synthesis of three different intermediate peptide fragments using solid-phase chemistry. Liquid-phase chemistry is then employed to add an amino acid product one of the fragments. The fragments are then linked with each other using solid and liquid phases. This invention can be used primarily to obtain insulinotropic peptides, such as GLP-1(7-36), and analogues thereof which may or many not occur under natural conditions.
EFFECT: use of pseudo-proline in one of the fragments makes solid-phase synthesis of said fragment easier and also makes easier subsequent linking of said fragment with other fragments in liquid phase.
20 cl, 1 dwg, 14 tbl, 15 ex
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