SEMISYNTHETIC TAXANE, INTERMEDIATE COMPOUNDS, METHODS OF SYNTHESIS AND PHARMACEUTICAL COMPOSITION Russian patent published in 1999 - IPC

Abstract RU 2134688 C1

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to a semisynthetic taxane of the formula (I) where R₁,R₂ is C_1-8-alkyl or phenyl; R₂ can mean also tert.-butoxy-group; when double bond is at positions 11, 12 then R³ is hydrogen atom; R⁴ - hydroxyl or C_2-8-acyloxy-group; when double bond is absent at positions 11, 12 then methyl at position 12 exhibits alpha-orientation; R³ - hydroxyl group or C_2-8-acyloxy-group; R⁴ - hydrogen atom and a pharmaceutical composition on its base that shows antitumor activity. EFFECT: improved method of synthesis, antitumor activity. 12 cl, 1 tbl, 11 ex

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RU 2 134 688 C1

Authors

Ehdzio Bombardelli

Paolo Deh Behllis

Bruno Gabetta

Dates

1999-08-20—Published

1995-07-21—Filed