FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to N, N'-diacetylcystine organic base salt in L-form (DiNAc) of the general formula -OOCCH(NHCOCH3)CH2S-SCH2CH(NHCOCH3)CH-COO- 2R+ or -OOCCH(NHCOCH3)CH2S-SCH2CH(NHCOCH3)CH-COO- R+ where R+ and R2+ - a cation of an organic base lysine, ethylenediamine, N,N'-dibenzylethyl- -enediamine, adamantaneamine, N-benzyl-2-phenylethylamine or piperazine. Compounds are synthesized by treatment of DiNAc with an organic base or salt containing cations of organic bases. New salts DiNAc are crystallized easily, they show chemical stability, immunomodulating activity and nonhygroscopicity. EFFECT: improved method of synthesis and properties of compounds. 9 cl, 2 tbl, 19 ex
Title |
Year |
Author |
Number |
DERIVATIVES OF 3,3′-DITHIOBIS-(PROPIONIC ACID) OR THEIR STEREOISOMERS AND COMPOSITION SHOWING IMMUNOMODULATING ACTION |
1991 |
- Karl-Magnus Aleksander Andersson[Se]
- Sten Khokan Aksel' Bergstrand[Se]
- Anders Rudol'F Khall'Berg[Se]
- Bengt Uljuf Sehrnstrand[Se]
- Per Anders Sigvard Tunek[Se]
|
RU2041208C1 |
SUBSTANCES EXHIBITING IMMUNOMODULATING EFFECT, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, METHOD OF IMMUNOMODULATION |
1991 |
- Karl-Magnus Aleksander Andersson
- Sten Khokan Aksel' Bergstrand
- Anders Rudol'F Khallberg
- Bengt Olof Sernstrand
- Per Anders Sigvard Tunek
|
RU2119793C1 |
PEPTIDE DERIVATIVES, THEIR STEREOISOMERS OR PHYSIOLOGICALLY ACCEPTABLE SALTS SHOWING ANTITHROMBOSIS, ANTICOAGULATING OR ANTI-INFLAMMATORY ACTIVITY, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION, METHOD OF SUPPRESSION OF THROMBIN ACTIVITY, METHOD OF INHIBITION OF KININOGENASES ACTIVITY, USE OF COMPOUNDS AS PARENT SUBSTANCES FOR SYNTHESIS OF THROMBIN INHIBITOR |
1994 |
- Karl Tomas Antonsson
- Rut Ehl'Vju Bjulund
- Nil'S David Gustafsson
- Nil'S Olov Ingemar Nil'Sson
|
RU2142469C1 |
THROMBIN INHIBITORS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, METHOD OF TREATMENT, METHOD OF THEIR SYNTHESIS (VERSIONS) AND PROTECTED DERIVATIVE |
1996 |
- Gustafsson David
- Njustrem Jan-Ehrik
|
RU2176645C2 |
THROMBIN INHIBITOR-CONTAINING AQUEOUS SOLUTION FOR NONPARENTERAL ADMINISTRATION SHOWING STABILITY AT STORAGE |
1995 |
- Ulla St'Ernfel'T
- Mats Sundgren
|
RU2164803C2 |
DERIVATIVES OF NAPHTHALENE AND DIHYDRONAPHTHALENE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, METHODS OF TREATMENT AND INTERMEDIATES SUBSTANCES |
1996 |
- Dzheffri Alan Dodzh
- Kennan Dzhozef Fehjkhi
- Charl'Z Dehvid Dzhouns
- Charl'Z Uillis Lugar
|
RU2167158C2 |
1-N-PHENYLAMINO-1H-IMIDAZOL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
2004 |
- Lafaj Zhan
- Rondo Benua
- Bonne Pol'
- Klerk T'Erri
- Shilds Zhaklin
- Djuk Igor
- Djuranti Ehrik
- Puksio Fransua
- Blo Kristian
- Mejllo Filipp
|
RU2365586C2 |
PHENYLATE DERIVATIVE, PRODUCTION, PHARMACEUTICAL COMPOSITION AND USE |
2017 |
- Fyn Chzhitsyan
- Chen Syaoguan
- Yan Yan
- Chzhou Chuan
- Laj Fanfan
- Tszi Min
- Tszin Syaofen
- Syue Nina
- Chzhen I
- Chen Khao
- Li Lin
|
RU2744975C2 |
BENZYLPHENYL ETHER DERIVATIVE, METHOD FOR PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF |
2017 |
- Fyn Chzhitsyan
- Chen Syaoguan
- Yan Yan
- Laj Fanfan
- Tszi Min
- Chzhan Litszin
- Chzhen I
- Syue Nina
- Van Ke
- Li Lin
|
RU2743165C2 |
1-HEXYL-4- PHENYL-4-BIPERIDINE CARBOXAMIDE N-SUBSTITUTED DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PROCESS FOR PREPARING THEREOF |
1992 |
- Anna-Lena Ask[Se]
- Rune Sandberg[Se]
|
RU2039043C1 |