BENZYLPHENYL ETHER DERIVATIVE, METHOD FOR PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF Russian patent published in 2021 - IPC C07C255/54 C07C233/36 C07C311/05 C07D319/18 C07D405/12 A61K31/277 A61K31/36 A61P31/00 A61P35/00 A61P37/00 

Abstract RU 2743165 C2

FIELD: pharmaceutics.
SUBSTANCE: present invention relates to benzylphenyl ether derivatives represented by the formula (IA-1), or to a pharmaceutically acceptable salt or stereoisomer thereof, and also to specific benzylphenyl ether derivatives structures of which are represented in the formula of the invention, or their pharmaceutically acceptable salt or stereoisomer that inhibits the interaction of PD-1/PD-L1. The invention also relates to a method for producing the claimed compounds, a pharmaceutical composition and the use of the claimed compounds.

In formula (IA-1) R2 is selected from cyano and methylsulfonyl; R3 is selected from

;

X is selected from hydrogen and chlorine.
EFFECT: invention enables effective production of benzylphenyl ether derivatives.

10 cl, 1 tbl, 28 ex

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RU 2 743 165 C2

Authors

Fyn Chzhitsyan

Chen Syaoguan

Yan Yan

Laj Fanfan

Tszi Min

Chzhan Litszin

Chzhen I

Syue Nina

Van Ke

Li Lin

Dates

2021-02-15Published

2017-05-23Filed