FIELD: pharmaceutics.
SUBSTANCE: present invention relates to benzylphenyl ether derivatives represented by the formula (IA-1), or to a pharmaceutically acceptable salt or stereoisomer thereof, and also to specific benzylphenyl ether derivatives structures of which are represented in the formula of the invention, or their pharmaceutically acceptable salt or stereoisomer that inhibits the interaction of PD-1/PD-L1. The invention also relates to a method for producing the claimed compounds, a pharmaceutical composition and the use of the claimed compounds.
In formula (IA-1) R2 is selected from cyano and methylsulfonyl; R3 is selected from
;
X is selected from hydrogen and chlorine.
EFFECT: invention enables effective production of benzylphenyl ether derivatives.
10 cl, 1 tbl, 28 ex
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Authors
Dates
2021-02-15—Published
2017-05-23—Filed