DERIVATIVES OF N-(3-PIPERIDINYLCARBONYL)-BETA-ALANINE AS ANTAGONISTS OF PLATELET ACTIVATION FACTOR, METHOD OF SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT Russian patent published in 2000 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes novel derivatives of N-(3-piperidinylcarbonyl)-beta-alanine of the general formula (I) where R¹ means piperidinyl that can has amino-protective group; R² means carboxy- or esterified carboxy-group; A¹ means C₁-C₆-alkylene, C₁-C₆-alkanyl-idene; A² means C₁-C₆-alkylene; A³ means C₁-C₆-alkylene that can has a single suitable substituent taken among the group including C₁-C₆-alkyl, C₂-C₆-alkenyl, C₁-C₆-alkynyl, cyano-, amino- -group, protected aminoacyl-group, C₁-C₆-alkylsulfonylamino- -C₁-C₆-alkyl, phenyl, phenyl-C₁-C₆-alkynyl, phenyl-C₁-C₆alkyl substituted with from 1 to 4 C₁-C₆-alkoxy-groups, halogen-C₁-C₆- alkyl, C₁-C₆-alkylenedioxy, C₁-C₆-alkyl substituted with unsaturated condensed 5-6-membered heterocyclic group containing from 1 to 4 nitrogen atoms, phenylsulfonyl-C₁-C₆- -alkyl and unsaturated 5-6-membered heterocyclic group containing from 1 to 4 nitrogen atoms; is the group where means piperidyl, tetrahydroquinolyl, pyrrolidinyl or morpholinyl; X means O or NH; Y means NH; Z means the group (a) where R³ is hydrogen atom or C₁-C₆-alkyl; l = 0 or 1; m = 0 or 1; n = 0 or 1, or its pharmaceutically acceptable salt. Novel compounds are antagonists of glyco-protein IIb/IIIa, inhibitors of platelet aggregation and inhibitors of binding fibrinogen with platelets. Invention describes also method of synthesis of proposed compounds, pharmaceutical preparation containing this compound and method of prophylaxis and/or treatment of patients or animals with diseases given in the description of invention. EFFECT: new compounds indicated above, improved method of synthesis, valuable medicinal properties. 32 cl, 1 tbl, 44 ex