STABILIZED PROTEIN-CONTAINING LYOPHILIZED COMPOSITION Russian patent published in 1999 - IPC

Abstract RU 2136306 C1

FIELD: medicine, pharmacy. SUBSTANCE: lyophilizate has buffer, alanine and mannitol at molar ratio alanine : mannitol = 1:(0.1-1). Enzyme urate oxidase, hormone hGH, interleukin-12 can be used as protein and phosphate buffer as a buffer. Alanine can be in crystalline form and mannitol - in an amorphous one. Protein containing in the composition retains stability at the room temperature. Water content in lyophilizate is compatible with protein activity retention. Invention can be used for making protein-containing preparations. EFFECT: improved quality and properties of the composition. 8 cl, 5 dwg, 5 tbl, 9 ex

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RU 2 136 306 C1

Authors

Alen Behjol

T'Erri Brel'

Patris Djupen

Filipp For

Dates

1999-09-10Published

1995-05-03Filed