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Application

97113917/13, 1997-07-31

(24)

Start date

1997-07-31

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Actual filing date

1997-07-31

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Published

1999-09-10

(72)

Inventor

Dal'Vadjants V.G.Kal'Noj S.M.Shchedrin V.I.Ljamkin G.I.

(73)

Holder

Stavropol'Skij Nauchno-Issledovatel'Skij Protivochumnyj Institut

METHOD OF PREPARING DIAGNOSTIC SERUM TO BRUCELLA IN R-FORM Russian patent published in 1999 - IPC

Abstract RU 2136315 C1

FIELD: microbiology. SUBSTANCE: culture of R-antigen is obtained from subcultures of the strain B. abortus that conserves R-form stably. For this purpose cells are incubated on the solid nutrient agar and separating flasks at 37 C under usual conditions and the grown culture is subjected for the control for its purity. Then the suspension of brucella living culture is prepared on physiological solution. The obtained antigen suspension is used for two-fold immunization of rabbits by intravenous fractional doses under condition of syringe needle removal. Rabbits are subjected for bleeding in 1 month after the last injection and serum is absorbed with S-antigens bacterial mass. Then procedure is controlled for the presence of agglutination to rough forms of brucella. EFFECT: simplified technology of serum production, increased yield. 1 ex

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RU 2 136 315 C1

Authors

Dal'Vadjants V.G.

Kal'Noj S.M.

Shchedrin V.I.

Ljamkin G.I.

Dates

1999-09-10—Published

1997-07-31—Filed

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