FIELD: veterinary microbiology. SUBSTANCE: method involves a single intravenous immunization of rabbits with a mixture of vaccine strains Brucella melitensis Rev-1, Brucella abortus 19 and Brucella suis 61 taken in the dose 2 x 109 CFU/ml of each strain in the volume 1 ml followed by animals bleeding in 2 weeks after termination of immunization. Serum is inactivated and phenol is added as a preserving agent. Invention can be used in production of polyvalent diagnostic brucellosis serum. EFFECT: accelerated process of ready preparation preparing, increased biological safety of process, high values of sensitivity of preparation.
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