IMIDAZOLE DERIVATIVES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS Russian patent published in 1999 - IPC

Abstract RU 2126004 C1

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of imidazole of the formula (I) where Y is H, phenyl, phenylalkyl, pyridyl, pyridylalkyl; Ar1 and Ar2 are phenylene; X and X1 are O, S, SO or SO2; R1 is H or alkyl; R2 and R3 are methylene, ethylene or propylene. Synthesized compounds show capacity to inhibit enzyme lipoxygenase. Compounds of the formula (I) can be used for treatment of patients with bronchial asthma, skin diseases and arthritis in mammals. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 9 cl, 51 ex

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RU 2 126 004 C1

Authors

Rodni V.Stivens

Takasi Mano

Kazuo Ando

Dates

1999-02-10Published

1994-05-25Filed