DERIVATIVES OF 5-PHENYL-3-(PIPERIDINE-4-YL)-1,3,4-OXADIAZOLE- -2(3H)-ONE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND DRUG Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of 5-phenyl-3-(piperidine-4-yl)-1,3,4-oxadiazole- -2(3H)-one of the general formula (I) where R₁ means the group (C₁-C₄)-alkyl or (C₃-C₇)-cycloalkylmethyl; X₁ means hydrogen or halogen atom or (C₁-C₄)-alkoxy-group or OR₁ and X₁ in common mean the group of the formula -OCH₂O-, -O(CH₂)₂-, -O(CH₂)₂O- or -O(CH₂)₃O-; X₂ means hydrogen atom or amino-group; X₃ means hydrogen or halogen atom and R₂ means hydrogen atom or possibly substituted group (C₁-C₆)-alkyl, or the group phenyl-(C₁C₄)-alkyl that can be substituted with phenyl ring, or the group phenyl-(C₂-C₃)-alkenyl, or the group phenoxy-(C₂C₄)-alkyl, or the group cyclo-(C₃-C₇)-alkylmethyl, or the group 2,3-dihydro-1H-indene-1-yl, or the group 2,3-dihydro-1H- -indene-2-yl, or the group of the general formula -(CH₂)_n-CO-Z where n = 1-6 and Z means the group piperidine-1-yl or 4-(dimethylamino)-piperidine-1-yl. Indicated compounds can be used for treatment and prophylaxis of disorders with implication of receptors 5-HT₄ and/or H₃, especially in the central nervous system, gastroenteric tract, lower urogenital organs or cardiovascular system. Invention describes method of synthesis of indicated compounds, pharmaceutical composition and drug also. EFFECT: improved method of synthesis, valuable medicinal and pharmacological properties. 7 cl, 1 tbl, 18 ex