FIELD: organic chemistry. SUBSTANCE: product: derivatives of 4-pyrimidinones or their organic or mineral pharmaceutical salts as three tautomeric forms. Reagent 1: β-ketoether: R1-CH2-CO-CH2-CO-COR4. Reagent 2: L-CH2C6H4-C6H4R5 where L - haloid, R5=COOR6, protected 1H-tetrazole-5-yl-group. Synthesized compound is interacted with amidine: HN=C(R2)NH2. The end product is isolated as free form or as organic or mineral pharmaceutical salts. Pharmaceutical composition containing vehicle and effective amount of 4-pyrimidinone as an active substance inhibits angiotensin-II fixation on blood receptors and can be used in medicine. EFFECT: improved method of synthesis, enhanced effectiveness. 4 cl, 2 tbl
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1993 |
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|
RU2111963C1 |
| ARYLALKYLAMINES AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1991 |
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RU2070196C1 |
| N-SUBSTITUTED HETEROCYCLIC DERIVATIVES OR THEIR SALTS, INTERMEDIATE DERIVATIVES OF PYRIMIDINE AND IMIDAZOLINE AND A PHARMACEUTICAL COMPOSITION BASED ON THE SUBSTITUTED HETEROCYCLIC DERIVATIVES |
1991 |
- Klod Bernar[Fr]
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RU2099331C1 |
| TRIAZOLEPYRIMIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITION SHOWING ANTAGONISTIC ACTIVITY WITH RESPECT TO ANGIOTENSIN II RECEPTORS |
1992 |
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RU2103270C1 |
| PYRIMIDINONE COMPOUNDS, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION |
1999 |
- Li Dzae-Khiojung
- Dzang Kijung-Dzin
- Joo Biojung-Vug
- Kim Dzi-Khan
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RU2233278C9 |
| DERIVATIVES OF 5-PHENYL-3-(PIPERIDINE-4-YL)-1,3,4-OXADIAZOLE- -2(3H)-ONE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND DRUG |
1996 |
- Zhegam Samir
- Lokkhed Alister
- Galli Frederik
- Nedelek Alen
- Solin'Jak Aksel'
- De Krju Lorans
|
RU2167160C2 |
| DERIVATIVES OF QUINOLINE-2(1H)-ONE, METHODS OF THEIR SYNTHESIS, DRUG AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1996 |
- Mak Kor Gari
- Khornar Kristian
- Dellak Zhenev'Ev
- Aletrju Mishel'
|
RU2167874C2 |
| SULFUR-CONTAINING IMIDAZOLE DERIVATIVES, METHOD OF THEIR SYNTHESIS, NEW INTERMEDIATE COMPOUNDS AND PHARMACEUTICAL COMPOSITION |
1991 |
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RU2086542C1 |
| PYRIDONE DERIVATIVES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1993 |
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- Bertran Ekkmann
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RU2124004C1 |
| DERIVATIVES OF BENZIMIDAZOLE OR THEIR ADDITIVE SALTS WITH ORGANIC OR MINERAL ACIDS, OR WITH MINERAL OR ORGANIC BASES, METHOD OF THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
1991 |
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