SEPARATION OF OPTICAL ISOMERS OF 2-(DIPHENYLMETHYL)-3-(2-METHOXY-5- ISOPROPYLPHENYL)METHIAMINO-1-AZABICYCLO-[2,2,2]-OCTANE Russian patent published in 1999 - IPC

Abstract RU 2136681 C1

FIELD: organic synthesis. SUBSTANCE: separation of racemic (±)-(2R,3R, 2S,3S)-2- (diphenylmethyl)-3-(2-methoxy-5-isopropylphenyl)methiamino-1- azabicyclo-[2,2,2] -octane consists in interaction thereof with 1R-(-)-10- camphorsulfonic acid in solvent to give 2S,3S-enantiomer after selective precipitation in the form of camphorsulfonic acid salt of formula I: (I) or in the form of free base. EFFECT: facilitated separation procedure. 10 cl

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RU 2 136 681 C1

Authors

Derek L.Tikner

Morgan Melts

Dates

1999-09-10Published

1996-07-04Filed