FIELD: medicine, narcology, analytical biochemistry. SUBSTANCE: method involves the use of the solid-phase immunoenzymatic analysis using rabbit blood serum at final dilution 1:1600 containing antibodies at titer 1:25600 and at contact affinity (Ka) 1,4•10 M. Sensitivity of method is 10 ng/ml that exceeds that of the known method by 25-fold. Method is used to enhance sensitivity of the method and its adaptation for determination of methadone in blood (serum, plasma). EFFECT: increased sensitivity of method. 2 tbl, 4 dwg, 2 ex
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