FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to biotechnology and immunology. There are presented various versions of antibodies with lower heterogeneity originating from the C-terminal of the H-chain that increases their stability in high concentrations.
EFFECT: presented antibodies possess improved physical-chemical properties (stability and heterogeneity), immunogenicity, safety and pharmacokinetics.
15 cl, 24 dwg, 5 tbl, 12 ex
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