PHOTOCONSOLIDATED DERIVATIVE OF GLYCOSEAMINOGLYCAN, CROSS- -LINKED DERIVATIVE OF GLYCOSEAMINOGLYCAN AND METHODS OF THEIR SYNTHESIS, COMPOSITION FOR MEDICINAL USE, METHOD OF PREVENTION OF CELLULAR AND TISSUE ADHESION Russian patent published in 1999 - IPC

FIELD: organic chemistry, natural polymers. SUBSTANCE: invention relates to a photoconso- -lidated derivative of glycoseaminoglycan of molecular mass 4 000-2 000 000 Da that can be presented by one of the following formulas: gag-O-CO-R¹, gag-OCO-R³-NH-CO-R¹, gag-O-CO-R³-O-CO-R¹, gag-CO-O-R³-NH-CO-R¹, gag-CO-NH-R³- -O-CO-R¹, gag-CO-NH-R³-NH-CO-R¹, gag-CO-O-R¹, gag-O-CO- -R³-CO-O-R¹, gag-CO-O-R³-CO-O-R¹, gag-CO-NH-R³-CO-O-R¹ where gag-O, gag-CO mean glycoseaminoglycan moiety and glycoseaminoglycan is taken among hyaluronic acid, chondroitin, chondroitin sulfate, dermatan sulfate, heparin, heparan sulfate, keratosulfate, keratopolysulfate, colominic acid or their derivatives; R¹ - a photoreactive group having at least one double C$C bond that is able to form cyclobutane ring by the photoreaction; R³ is (CH₂)_n-, -(CH₂)_pCHY-, -(CH₂)_m-C₆H₄-(CH₂)_l- where l, m, n, p - a number from 1 to 19; Y is COOH, NH₂. Compounds exhibit the high degree of safety and biocompatibility. EFFECT: improved method of synthesis, valuable properties. 15 cl, 10 tbl, 23 dwg, 29 ex