FIELD: organic chemistry, natural polymers. SUBSTANCE: invention relates to a photoconso- -lidated derivative of glycoseaminoglycan of molecular mass 4 000-2 000 000 Da that can be presented by one of the following formulas: gag-O-CO-R1, gag-OCO-R3-NH-CO-R1, gag-O-CO-R3-O-CO-R1, gag-CO-O-R3-NH-CO-R1, gag-CO-NH-R3- -O-CO-R1, gag-CO-NH-R3-NH-CO-R1, gag-CO-O-R1, gag-O-CO- -R3-CO-O-R1, gag-CO-O-R3-CO-O-R1, gag-CO-NH-R3-CO-O-R1 where gag-O, gag-CO mean glycoseaminoglycan moiety and glycoseaminoglycan is taken among hyaluronic acid, chondroitin, chondroitin sulfate, dermatan sulfate, heparin, heparan sulfate, keratosulfate, keratopolysulfate, colominic acid or their derivatives; R1 - a photoreactive group having at least one double C
$C bond that is able to form cyclobutane ring by the photoreaction; R3 is (CH2)n-, -(CH2)pCHY-, -(CH2)m-C6H4-(CH2)l- where l, m, n, p - a number from 1 to 19; Y is COOH, NH2. Compounds exhibit the high degree of safety and biocompatibility. EFFECT: improved method of synthesis, valuable properties. 15 cl, 10 tbl, 23 dwg, 29 ex
Title |
Year |
Author |
Number |
SUCCINIC ACID DERIVATIVES, SUCCINIC ACID-POLYSACCHARIDE DERIVATIVE, METHOD OF PREPARING SUCCINIC ACID-GLYCOSAMINOGLYCANE DERIVATIVE, METHOD OF PREPARING SUCCINIC ACID-POLYAMINOSACCHARIDE DERIVATIVE, AND METHOD OF PREPARING CROSS- LINKED SUCCINIC ACID-POLYSACCHARIDE DERIVATIVE |
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