FIELD: organic chemistry, pharmacy, cosmetics. SUBSTANCE: invention describes new bicyclic aromatic compounds of the general formula (I) where R1 - the group CO-O-R8 where R8 - hydrogen atom, alkyl, linear or branched radical with 1-20 carbon atoms or COR where R - lower alkyl; A - a radical taken among the group: (a)
, (b)
, (d)
; X means -O-, S(O)t or -NR9-; R2 - hydrogen, halogen atom, lower alkyl, group OR9; t - the whole number 0, 1 or 2; R9 - hydrogen, halogen atom, lower alkyl, the group OR9; t - the whole number 0, 1 or 2; R9 - hydrogen atom or lower alkyl; R11 and R12 - hydrogen atom or lower alkyl or their salts. Compounds show the activity with respect to cellular differentiation and proliferation. Invention describes also pharmaceutical and cosmetic compositions based on compounds of the formula (I). EFFECT: valuable biological properties of compounds. 14 cl, 1 dwg, 27 ex
Authors
Dates
1999-11-20—Published
1995-04-25—Filed