METHOD OF SYNTHESIS OF DERIVATIVES OF 2-AMINOTHIAZOLE CARBOXAMIDE Russian patent published in 2002 - IPC

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention relates to method of synthesis of derivatives of 2-aminothiazole carboxamide of the formula (I) where R¹ means C_1-5-alkyl with direct or branched chain; R² means C_1-3-alkyl by interaction of compound of the formula (II) where R³ means phenyl that can be optionally mono-penta-substituted independently with chlorine atom, methoxy-, ethoxy-, phenoxy- or nitro-group with compound of the formula (III) where Y means removing group in solvent in the presence of a base. Invention relates also to compound of the formula (II) where R¹ means C_1-5-alkyl with direct of branched chain; R² means C_1-3-alkyl; R³ means phenyl that can be optionally mono-penta-substituted independently with chlorine atom, methoxy-, ethoxy-, phenoxy- or nitro-group, and compound of the formula (III) where Y means chlorine or bromine atom. EFFECT: improved method of synthesis of 2-aminothiazole carboxamide. 10 cl, 1 tbl, 13 ex