FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to derivatives of pyridine of the formula (I)
where M means -NR3; R3 - hydrogen atom or the group -NR4-D-TR5 where T means N; D is C2-3-alkylene group; R4,R5 in common mean C2-3-alkylene group; X - a simple bond, C1-4-alkylene group, phenylenecarbonyl, C1-2-alkylenecarbonyl, C1-2-alkylenecarbonyloxy-, C1-2-alkylene-CONH-, C1-4-alkylene-oxy-group (other values see p. 1 of the invention claim). Compounds show ability to inhibit platelet aggregation and inhibit fibrinogen binding with GPIIb/IIIa. EFFECT: valuable pharmacological properties of compounds. 16 cl, 1 tbl, 157 ex
Title |
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Author |
Number |
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