DERIVATIVES OF BICYCLED AMIDES, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT OF PATIENTS WITH PATHOLOGICAL AND INFLAMMATORY STATES Russian patent published in 1999 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention describes new derivatives of BICYCLED amides of the general formula (I) where R¹,R²,R³,R⁴ are taken (each) among hydrogen and fluorine atom and at least one and not more two of their mean fluorine atom; R⁵ is taken among hydrogen atom and C₁-C₄-alkyl; R⁶ is taken among hydrogen atom, C₁-C₄-alkyl and hydroxy-group or R⁵ and R⁶ in common with ring carbon form the carbonyl group; R⁷ is taken among hydrogen atom and hydroxy-group; R⁸ and R⁹ are taken (each) among hydrogen atom, C₁-C₄-alkyl and cyclo-(C₃ or C₄)-alkyl or in common with nitrogen atom form morpholino-group, their salts and solvates. Invention describes also pharmaceutical compositions based on compounds of the formula (I) that are used in medicine, in part, as muscle relaxants. Invention describes also a method of treatment of patients with pathological and inflammatory states. Compounds of the formula (I) shows decreased ability to induce sedative effect and coordination disorder as compared with the known agents. EFFECT: enhanced effectiveness of compounds as curative agents. 31 cl, 86 ex