FIELD: organic synthesis and biologically-active compounds. SUBSTANCE: invention provides new pyrido[3,2-e] pyrazinones of general formula I: 
(I), wherein X, Y, and Z are nitrogen or group CR3, provided that at least one of X, Y, Z is nitrogen; R1 is optionally aryl- substituted C1-C10-alkyl; R2 hydrogen, C5-C7-cycloalkyl, or C1-C10-alkyl optionally substituted by radical selected from group including aryl, aryloxy, hydroxyl, sulfonyl, pyridyl, and quinolyl; A is methylene, group NR3, or oxygen atom; R3 hydrogen or C1-C6-alkyl; or their physiologically tolerable salts exhibiting anti-asthmatic and antiallergenic effects. EFFECT: increased choice of pharmaceutically active compounds. 8 cl, 2 tbl, 53 ex
| Title | Year | Author | Number |
|---|---|---|---|
| N-SUBSTITUTED INDOLE-3-GLYOXYLAMIDES AND MEDICINAL PREPARATION ELICITING ANTI-ASTHMATIC, ANTI-ALLERGIC AND IMMUNODEPRESSIVE/IMMUNOMODULATING EFFECT, METHOD FOR PREPARING COMPOUNDS (VARIANTS) AND METHOD FOR PREPARING MEDICINAL PREPARATION | 1997 |
|
RU2237661C2 |
| DEUTERATED BENZYL BENZENE DERIVATES AND METHODS FOR USE | 2009 |
|
RU2509773C2 |
| METHOD OF SUPPRESSION OF PHYTOPATHOGEN FUNGI, DERIVATIVE OF BENZOPHENONE, A METHOD OF PROTECTION OF PLANTS FROM DAMAGE CAUSED BY PHYTOPATHOGEN FUNGUS, A FUNGICIDE COMPOSITION, METHODS OF SYNTHESIS OF BENZOPHENONES | 1996 |
|
RU2129788C1 |
| IMINOOXIMETHYLENEANILIDES, METHOD OF PREPARATION THEREOF (VERSIONS), PEST-CONTROL AGENTS, PEST-CONTROL METHOD, AND INTERMEDIATE COMPOUNDS | 1995 |
|
RU2143423C1 |
| 2-IMINOOXYPHENYL ACETIC ACID DERIVATIVES, AND AGENT COMPRISING SAID COMPOUNDS | 1996 |
|
RU2170229C2 |
| PREPARATION OF HYDROXY-BENZYLBENZENE DERIVATIVES | 2014 |
|
RU2671493C2 |
| AMINOGUAMIDINES, METHOD OF PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION BASED THEREON | 1992 |
|
RU2095347C1 |
| SUBSTITUTED DERIVATIVES OF PYRAZINE AND HERBICIDE AGENT BASED ON THEREOF | 1995 |
|
RU2155756C2 |
| ANTAGONISTS OF LUTEINIZING HORMONE RELEASING-FACTOR (VARIANTS), METHOD OF THEIR SYNTHESIS (VARIANTS), PHARMACEUTICAL COMPOSITION AND METHOD OF MEDICINAL PREPARATIONS PREPARING | 1996 |
|
RU2163910C2 |
| IMMUNOFYLLINE-SPECIFIC LIGANDS AS ANTIASTHMATIC AND IMMUNO-DEPRESSANT AGENTS AND METHOD OF THEIR SYNTHESIS, PHARMACEUTICALLY READY FORM, MEDICINAL AGENT AND METHOD OF ITS PREPARING | 1997 |
|
RU2172743C2 |
