FIELD: organic chemistry and technology. SUBSTANCE: 6,9-bis-[(2-aminoethyl)- -amino[g] isoquinoline-5,10-dione maleate is synthesized by the following manner. 6,9-Difluorobenzo[g]isoquinoline-5,10-dione is added slowly to ethylenediamine solution in tetrahydrofuran and 6,9-bis-[(2-aminoethyl)-amino]benzo[g]isoquinoline-5,10-dione dihydrofluoride salt is formed. The the latter is dissolved in water and acetic acid at pH 5, filtered off and maleic acid solution is added. The proposed improved methods ensure to obtain the end compound at purity degree above 97%. EFFECT: improved methods of synthesis, increased purity of the compound. 10 cl, 22 tbl, 39 ex
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Year |
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Number |
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