ERYTHROMYCIN DERIVATIVES, METHOD OF PREPARATION THEREOF, INTERMEDIATE, AND PHARMACEUTICAL COMPOSITION Russian patent published in 2000 - IPC

FIELD: synthesis of biologically- active compounds. SUBSTANCE: invention provides new erythromycin derivatives depicted by general formula I: (I), in which R and R₁ are hydroxyl or O-C₂-10₁₀-acyl; R₂ methyl; R₃ is ether radical -(CH₂)_mR₄ with m=4 or radical -N-(CH₂)_qR₄ with q= 3; and R₄ is optionally phenyl-substituted heterocyclic mono- or polycyclic radical such as imidazolyl, pyridyl, thiazolyl, quinolinyl, or 3H-imidazo[4,5-b] pyridyl or their additive salts with acids. Compounds I exhibit important antibiotic properties. EFFECT: enlarged choice of antibiotics. 13 cl, 1 tbl, 10 ex