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2 144 954

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IPC

(21) (22)

Application

98107308/13, 1998-04-15

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Start date

1998-04-15

(22)

Actual filing date

1998-04-15

(45)

Published

2000-01-27

(72)

Inventor

Livshits V.A.Chesnokova V.L.Aleshin V.V.Sokurenko E.V.Dalin M.V.Kravtsov Eh.G.Bykov V.A.

(73)

Holder

Livshits Vitalij Arkad'Evich

STRAIN OF BACTERIUM ESCHERICHIA COLI M17/P COLAP USED FOR PROBIOTIC PREPARATION PRODUCING Russian patent published in 2000 - IPC

Abstract RU 2144954 C1

FIELD: biotechnology, microbiology. SUBSTANCE: invention relates to producing substances used for preparing probiotic preparations - bacteritic preparations based on live cultures of microorganism-symbionts used for prophylaxis and treatment of dysbacteriosis and other disorders of gastroenteric tract. Method involves insertion of nonconjugative nonmobilized plasmid pColap carrying genes encoding colicin E1 and factor that determines resistance to ampicillin (doses up to 150 mg/l) into the strain of Escherichia coli M17 - producer of probiotic preparation coli-bacterin. This approach ensures to construct the probiotic preparation showing enhanced antagonistic activity and residence on background of therapy with antibiotics carrying out. Method alleviates preparing the standard preparation based on the strain and prevents elimination of plasmid if patient intakes the preparation without accompanying therapy with antibiotics. EFFECT: strain indicated above, valuable properties and traits. 2 dwg, 1 tbl, 2 ex

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RU 2 144 954 C1

Authors

Livshits V.A.

Chesnokova V.L.

Aleshin V.V.

Sokurenko E.V.

Dalin M.V.

Kravtsov Eh.G.

Bykov V.A.

Dates

2000-01-27—Published

1998-04-15—Filed