FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes the method of producing lamotrigine of the formula (I) 
or its pharmaceutically acceptable salt obtained by acid addition that are used for treatment of patients with the central nervous system disorders. Compound of the formula (II) 
where R means CN is subjected for ultraviolet or visible light irradiation in organic solvent at heating followed by if necessarily conversion of the end product to its pharmaceutically acceptable salt by treatment with acid. Invention describes intermediate compounds and the method of pharmaceutical composition preparing also. EFFECT: improved method of producing, valuable pharmacological properties. 13 cl, 15 ex
| Title |
Year |
Author |
Number |
| METHOD OF SYNTHESIS OF LAMOTRIGINE AND INTERMEDIATE COMPOUND USED FOR ITS SYNTHESIS |
1995 |
|
RU2162081C2 |
| SUBSTITUTED CARBOCYCLIC AMIDES, METHODS OF PREPARATION THEREOF, INDANE DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHODS OF PROPHYLAXIS OR MEDICAL TREATMENT |
1995 |
- Masso Dejvid Li
- Kelli Dzhejmz Leroj
|
RU2145954C1 |
| 1,4-BENZOTHIAZEPINE-1,1-DIOXIDE, PHARMACEUTICAL COMPOSITION DECREASING BLOOD LIPID LEVEL, METHOD OF TREATMENT OF MAMMAL CLINICAL STATE, METHOD OF SYNTHESIS OF COMPOUND |
1995 |
|
RU2156245C2 |
| DERIVATIVES OF 5,6-DICHLOROBENZIMIDAZOLE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT AND PROPHYLAXIS OF VIRAL INFECTIONS |
1995 |
- Chejmberlejn Stehnli Doz
- Koszalka Dzhordzh Uolter
|
RU2145963C1 |
| CHLOROPYRIMIDINE INTERMEDIATE COMPOUNDS |
1995 |
- Dehjljudzh Sjuzen Mehri
- Martin Majkl Tolar
- F'Judzhett Mishell' Dzhoann Ferri
|
RU2140913C1 |
| PHARMACEUTICAL COMPOSITION CONTAINING LAMOTRIGIN |
1995 |
- Khiskett Sajmon Filip
- Tejlor S'Juzen Ehnn
|
RU2160106C2 |
| 4-AMINO-2-(4-METHYLPIPERAZINE-1-YL)-5-(2,3,5-TRICHLOROPHENYL)- -PYRIMIDINE AND ITS SALTS OF ACID ADDITION, METHODS OF THEIR SYNTHESIS (VARIANTS) AND PHARMACEUTICAL COMPOSITION |
1989 |
- Miller Ehlistehjr Ehjnsli
- Nobbz Mal'Kol'M Stjuart
- Gajd Richard Martin
- Lich Majkl Dzhon
|
RU2171256C2 |
| METHOD OF PRODUCING TRIAZINE OR ACID-ADDITIVE SALTS THEREOF |
0 |
- Dzheffri Allan
- Alistejr Ajnsli Miller
- David Alan Sojer
|
SU1371500A3 |
| PROCESS FOR PREPARING DERIVATIVES OF 3,5-DIAMINO-1,2,4-TRIAZINE OR THEIR ACID ADDITION SALTS |
0 |
- Martin Dzhordzh Bakster
- Albert Redzhinald-Elfik
- Alister Ajnsli Miller
|
SU1055331A3 |
| 4-[2-AMINO-6-(CYCLOPROPYLAMINO)-9H-PURINE-9-YL]-2-CYCLOPENTENE- -1-METHANOL SUCCINATE AS ANTIVIRAL AGENT |
1995 |
- Dehjljudzh S'Juzen Meri
- Uilson Dzheffri Daglas
|
RU2145324C1 |
