FIELD: pharmaceutical industry. SUBSTANCE: composition contains, wt %: lamotrigin or its tolerable acid-addition salt 0.5-50, lactose 15-50, starch 15-50, crystalline cellulose 0.5-15, and polyvinylpyrrolidone 5-15. Composition appears as freely flowing powder composed of granules with particle size up to 850 mcm, of which at least 90% are 75 to 850 mcm in size. Preparation procedure: lamotrigin, lactose, maize starch, and crystalline cellulose are subjected to spray granulation in presence of polyvinylpyrrolidone as binding agent. Disintegration of granules takes 30 min. During this time, at least 90% of lamotrigin dissolves in granules. EFFECT: increased stability under high-temperature and high-humidity conditions. 3 cl, 6 tbl, 3 ex
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