FIELD: organic chemistry. SUBSTANCE: invention describes method of synthesis of lamotrigine of the formula (I) 
or its pharmaceutically acceptable salt prepared by acid addition. Method of synthesis involves treatment of 6-(2,3-dichlorophenyl)-5-chloro-3-thiomethyl-1,2,4-triazine of the formula (II) 
with ammonia. Compound is used for treatment of patients with disorders of central nervous system, in part, epilepsy. Invention describes also the novel intermediate compound used for its synthesis. EFFECT: new intermediate compound, simplified synthesis. 10 cl, 11 ex
| Title |
Year |
Author |
Number |
| METHOD OF LAMOTRIGINE PRODUCING, INTERMEDIATE COMPOUNDS AND METHOD OF PHARMACEUTICAL COMPOSITION PREPARING |
1995 |
- Uinter Rejmond Dzheffri
- Sojer Dejvid Alan
- Dzhermejn Ehndr'Ju
|
RU2145602C1 |
| SUBSTITUTED CARBOCYCLIC AMIDES, METHODS OF PREPARATION THEREOF, INDANE DERIVATIVES, PHARMACEUTICAL COMPOSITION AND METHODS OF PROPHYLAXIS OR MEDICAL TREATMENT |
1995 |
- Masso Dejvid Li
- Kelli Dzhejmz Leroj
|
RU2145954C1 |
| 1,4-BENZOTHIAZEPINE-1,1-DIOXIDE, PHARMACEUTICAL COMPOSITION DECREASING BLOOD LIPID LEVEL, METHOD OF TREATMENT OF MAMMAL CLINICAL STATE, METHOD OF SYNTHESIS OF COMPOUND |
1995 |
|
RU2156245C2 |
| DERIVATIVES OF 5,6-DICHLOROBENZIMIDAZOLE, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT AND PROPHYLAXIS OF VIRAL INFECTIONS |
1995 |
- Chejmberlejn Stehnli Doz
- Koszalka Dzhordzh Uolter
|
RU2145963C1 |
| PHARMACEUTICAL COMPOSITION CONTAINING LAMOTRIGIN |
1995 |
- Khiskett Sajmon Filip
- Tejlor S'Juzen Ehnn
|
RU2160106C2 |
| PYRIMIDINE DERIVATIVES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION |
1989 |
- Ehlistehjr Ehjnsli Miller
- Mal'Kol'M Stjuart Nobbz
- Richard Martin Gajd
- Majkl Dzhon Lich
|
RU2121998C1 |
| 4-[2-AMINO-6-(CYCLOPROPYLAMINO)-9H-PURINE-9-YL]-2-CYCLOPENTENE- -1-METHANOL SUCCINATE AS ANTIVIRAL AGENT |
1995 |
- Dehjljudzh S'Juzen Meri
- Uilson Dzheffri Daglas
|
RU2145324C1 |
| 4-AMINO-2-(4-METHYLPIPERAZINE-1-YL)-5-(2,3,5-TRICHLOROPHENYL)- -PYRIMIDINE AND ITS SALTS OF ACID ADDITION, METHODS OF THEIR SYNTHESIS (VARIANTS) AND PHARMACEUTICAL COMPOSITION |
1989 |
- Miller Ehlistehjr Ehjnsli
- Nobbz Mal'Kol'M Stjuart
- Gajd Richard Martin
- Lich Majkl Dzhon
|
RU2171256C2 |
| CHLOROPYRIMIDINE INTERMEDIATE COMPOUNDS |
1995 |
- Dehjljudzh Sjuzen Mehri
- Martin Majkl Tolar
- F'Judzhett Mishell' Dzhoann Ferri
|
RU2140913C1 |
| METHOD OF PRODUCING TRIAZINE OR ACID-ADDITIVE SALTS THEREOF |
0 |
- Dzheffri Allan
- Alistejr Ajnsli Miller
- David Alan Sojer
|
SU1371500A3 |
