FIELD: biochemistry, nucleotides. SUBSTANCE: method involves interaction of 3'-silylated-5'-protected nucleoside with nonprotected nucleoside in solvent in the presence of basic catalyst that makes steric hindrances. Silylated and nonprotected nucleosides can be either monomeric nucleosides or terminal nucleosides of oligonucleotides or oligonucleotide analogs. EFFECT: improved method of linkage. 15 cl
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