NUCLEASE-RESISTANT OLIGONUCLEOSIDES, METHOD OF PREPARING THEREOF, AND NUCLEASE-RESISTANT NUCLEOSIDE DIMER Russian patent published in 1999 - IPC

FIELD: biochemistry. SUBSTANCE: described is new nuclease-resistant oligonucleoside containing sequence of general formula I: wherein each Z is independently R¹ or wherein W is -D-D-D- wherein each D is independently CHR or NR⁶ wherein R is independently hydrogen, OH, and R⁶ is hydrogen provided that only one of D is NR⁶, W′ is independently W or , R¹ is independently OH, SH or NR²R³ wherein R² and R³ are independently H or C₁-C₆- alkyl, each R⁵ is independently H or C₁-C₁₂ alkyl, each Y is independently H or OH, each B is independently adenine, citosine, guanine, thymine, uracil or modifications thereof, each e and f is integer from 0 to 50 provided that at least one of each f is at least 1, j is integer from 1 to about 200, K is 0 or integer from 1 to about 197, and each of m and n is independently from 1 to 200, each P is independently integer from 2 to 4; Q is either from 1 to about 197 provided that sum j+k+Q is from about 5 to 200. EFFECT: improved properties of the nuclease-resistant oligonucleosides. 9 cl, 42 ex, 9 tbl