DERIVATIVES OF PYRROLOPYRIDAZINE, METHODS OF THEIR SYNTHESIS, ANTIULCER AGENT Russian patent published in 2000 - IPC

Abstract RU 2146257 C1

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes new derivatives of pyrrolo-pyridazine of the general formula (I) where values R1-R5, m, n, A, X are given in p. 1 of the invention claim. Derivatives of pyrrolopyridazine show high activity inhibiting secretion of gastric juice, activity protecting stomach mucosa membrane and antibacterial activity against Helicobacter pylori. Therefore indicated derivatives can be used as prophylactic or therapeutic agents for prevention or treatment of patients with ulcer diseases. Invention describes the method of their synthesis and an antiulcer agent also. EFFECT: improved method of synthesis, enhanced effectiveness of agent. 27 cl, 123 ex

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RU 2 146 257 C1

Authors

Tomio Kimura

Josimi Fudzikhara

Nobukhiko Sibakava

Khirosi Fudzivara

Ehtsuro Itokh

Kejdzi Matsunobu

Kejiti Tabata

Khirosi Jasuda

Dates

2000-03-10Published

1995-01-18Filed