FIELD: organic chemistry, pharmacy. SUBSTANCE: invention describes new derivatives of pyrrolo-pyridazine of the general formula (I) where values R1-R5, m, n, A, X are given in p. 1 of the invention claim. Derivatives of pyrrolopyridazine show high activity inhibiting secretion of gastric juice, activity protecting stomach mucosa membrane and antibacterial activity against Helicobacter pylori. Therefore indicated derivatives can be used as prophylactic or therapeutic agents for prevention or treatment of patients with ulcer diseases. Invention describes the method of their synthesis and an antiulcer agent also. EFFECT: improved method of synthesis, enhanced effectiveness of agent. 27 cl, 123 ex
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Authors
Dates
2000-03-10—Published
1995-01-18—Filed