IMPROVED PEPTIDE, IMMUNOGENIC COMPOSITION AND VACCINE USING THE PEPTIDE AND METHOD FOR IMMUNIZING ANIMALS AGAINST LUTEINIZING HORMONE- RELEASING HORMONE Russian patent published in 2000 - IPC

FIELD: medicine. SUBSTANCE: peptide has at least two adjacent tandem decapeptide sequences of luteinizing hormone-releasing hormone with general formula (where N-end amino acid is positioned on the left and C-end on the right): Z¹-Glx-His-Trp¹-Ser-Tyr-Gly-Leu-Arg-Pro[-Gly-X-Gln- His-Trp²-Ser-Tyr-Gly-Leu-Arg-Pro] _n-Gly-Z², where amino acids are denoted using three-letter code, Trp¹ and Trp² correspond to tryptophan (Trp) or formylated tryptophan (N-(indole)-formyl- tryptophan ), n is the number equal to at least 1, X is the direct bond or spacer group between the Gly and Gln amino acids, Z¹-Glx-Glx represents pGlu (pyruglutaminic acid) or Gln bound to the tail having at least one additional amino acids. Glycine amino acid in position 6 of at least one from the luteinizing hormone-releasing hormone decapeptides is substituted with right- rotation acid. EFFECT: enhanced effectiveness of vaccine. 13 cl, 5 tbl