FIELD: genetic engineering, biochemistry, enzymes. SUBSTANCE: recombinant neuraminidase of influenza type NA2 is prepared by culturing insect infected cells or yeast cells in a suitable medium. Insect cells are infected with virus transformed by homologous recombination of its genome using the expression vector pPP1IVNAflS. Recombinant neuraminidase is used in vaccine against influenza. Invention provides to prepare vaccine showing effectiveness against influenza virus type NA2. EFFECT: improved method of preparing, enhanced effectiveness of vaccine. 3 cl, 20 dwg, 2 tbl, 3 ex
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