METHOD OF SYNTHESIS OF DIHALOIDAZOLOPYRIMIDINES AND METHOD OF SYNTHESIS OF DIHYDROXYAZOLOPYRIMIDINES Russian patent published in 2000 - IPC

Abstract RU 2147584 C1

FIELD: organic chemistry, chemical technology. SUBSTANCE: invention describes the effective and efficient method of synthesis of dihaloidazo-lopyrimidine of the following structural formula (I): . Method involves interaction of malonic acid ether of the formula (II) with heteroazolylamine of the formula (III) to yield an intermediate salt that can be optionally acidified to form dihydroxyazolopyrimidine of the formula (IV) . Then salt or dihydroxyazolopyrimidine is subjected for halogenation. EFFECT: improved method of synthesis. 28 cl, 2 tbl, 5 ex

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RU 2 147 584 C1

Authors

Gjunter Krummel'

Karl-Otto Shtumm

Klaus-Jjurgen Pes

Peter Khejnts Rudi Liers

Dates

2000-04-20Published

1996-09-30Filed