FIELD: organic chemistry, chemical technology, pharmacy. SUBSTANCE: invention describes the novel derivatives of benzofuranone of the general formula (I) 
where each of R1-R5 means hydrogen atom, hydroxyl-group, direct or branched alkyl, alkylhydroxy- or aralkylhydroxy-group containing 1-7 carbon atoms, halogen atom, amino-group or alkylenedihydroxy-group bound respectively by the point of R1 and R2, R2 and R3, R3 and R4 or R4 and R5, means hydroxyl-group, direct or branched alkoxy- or aralkylhydroxy-group containing 1-7 carbon atoms or carboxylic acid ester residue containing 1-7 carbon atoms. Compounds show inhibiting effect on activity of 17-β--hydroxysteroid dehydrogenase. Invention describes also method of their synthesis and medicinal and therapeutic agent based on thereof. EFFECT: new derivatives indicated above, improved method of synthesis. 5 cl, 8 tbl
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