FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to heterobicyclic derivatives of the formula (I) 
and their pharmaceutically acceptable salts that show inhibitory activity with respect to phosphodiesterase-IV and suppressing effect on tumor necrotic factor. Invention describes 5 methods of synthesis of derivatives of pyridopyrazine of the formula (I). EFFECT: improved methods of synthesis, valuable biochemical and medicinal properties. 15 cl, 115 ex
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